Scott Cuthbert is banned for Luton's home clash with bottom club Port Vale.
The defender was sent off for pulling back Keshi Anderson as the Hatters went on to lose 3-0 to Swindon at Kenilworth Road on Saturday.
James Collins played 90 minutes of that game despite concerns over a hip injury and he is likely to lead the line once again.
Glen Rea was dropped for the Robins clash, only to benefit from Cuthbert's first-half dismissal as he was brought on for Andrew Shinnie, and he is likely to come into Nathan Jones' starting line-up.
Port Vale will be without winger Cristian Montano after he tore a hamstring in training on Thursday.
The summer signing had only recently resumed training and now faces a lengthy spell on the sidelines.
The Valiants, who slipped to the foot of the table following a 1-0 defeat against Coventry on Saturday, will also be without goalkeeper Rob Lainton.
Lainton, who has been struggling with a quad injury this season, went over on his ankle in the Sky Blues clash and had it put in a cast. Sam Hornby will start in his place.